Green Hearts
No Result
View All Result
  • Home
  • World
  • Business
  • Sports
  • Agriculture
  • Nature
  • Animals
  • Economy
  • Education
  • Entertainment
  • Life Style
  • Travel
Green Hearts
No Result
View All Result
ADVERTISEMENT
Home Nature

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

Green Hearts by Green Hearts
May 18, 2022
in Nature
396 4
0
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis
550
SHARES
2.5k
VIEWS
Share on FacebookShare on Twitter

RelatedPosts

it's almost time to get wild about nature – YourSun.com

it's almost time to get wild about nature – YourSun.com

March 25, 2023
Hear Rickie Lee Jones’ Enchanting ‘Nature Boy’ Cover – JamBase

Hear Rickie Lee Jones’ Enchanting ‘Nature Boy’ Cover – JamBase

March 25, 2023
Russian occupation administration takes over the Askaniia-Nova nature reserve – Yahoo News

Russian occupation administration takes over the Askaniia-Nova nature reserve – Yahoo News

March 25, 2023
Nature: Migrants' travels as interesting as the birds – Waterbury Republican American

Nature: Migrants' travels as interesting as the birds – Waterbury Republican American

March 25, 2023


  • Gupta, P. B., Pastushenko, I., Skibinski, A., Blanpain, C. & Kuperwasser, C. Phenotypic plasticity: driver of most cancers initiation, development, and remedy resistance. Cell Stem Cell 24, 65–78 (2019).

    CAS 
    PubMed 

    Google Scholar 

  • Vitale, I., Shema, E., Loi, S. & Galluzzi, L. Intratumoral heterogeneity in most cancers development and response to immunotherapy. Nat. Med. 27, 212–224 (2021).

    CAS 
    PubMed 

    Google Scholar 

  • Lüönd, F., Tiede, S. & Christofori, G. Breast most cancers for example of tumour heterogeneity and tumour cell plasticity throughout malignant development. Br. J. Cancer 125, 164–175 (2021).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Bergers, G. & Fendt, S. M. The metabolism of most cancers cells throughout metastasis. Nat. Rev. Cancer 21, 162–180 (2021).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Prasetyanti, P. R. & Medema, J. P. Intra-tumor heterogeneity from a most cancers stem cell perspective. Mol. Cancer 16, 41 (2017).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Pastushenko, I. & Blanpain, C. EMT transition states throughout tumor development and metastasis. Trends Cell Biol. 29, 212–226 (2019).

    CAS 
    PubMed 

    Google Scholar 

  • Locasale, J. W. et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43, 869–874 (2011).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Possemato, R. et al. Functional genomics reveal that the serine synthesis pathway is crucial in breast most cancers. Nature 476, 346–350 (2011).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Rinaldi, G. et al. In vivo proof for serine biosynthesis-defined sensitivity of lung metastasis, however not of main breast tumors, to mTORC1 inhibition. Mol. Cell 81, 386–397 (2021).

    CAS 
    PubMed 

    Google Scholar 

  • Ngo, B. et al. Limited environmental serine and glycine confer mind metastasis sensitivity to PHGDH inhibition. Cancer Discov. 10, 1352–1373 (2020).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Geeraerts, S. L. et al. Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor progress. Mol. Cancer Ther. 20, 50–63 (2020).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Pacold, M. E. et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit destiny. Nat. Chem. Biol. 12, 452–458 (2016).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Schmidt, J. M. et al. Stem-cell-like properties and epithelial plasticity come up as secure traits after transient Twist1 activation. Cell Rep. 10, 131–139 (2015).

    CAS 
    PubMed 

    Google Scholar 

  • Noh, S., Kim, D. H., Jung, W. H. & Koo, J. S. Expression ranges of serine/glycine metabolism-related proteins in triple damaging breast most cancers tissues. Tumour Biol. 35, 4457–4468 (2014).

    CAS 
    PubMed 

    Google Scholar 

  • Pascual, G. et al. Targeting metastasis-initiating cells via the fatty acid receptor CD36. Nature 541, 41–45 (2017).

    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Oshimori, N., Oristian, D. & Fuchs, E. TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma. Cell 160, 963–976 (2015).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Margarido, A. S., Bornes, L., Vennin, C. & van Rheenen, J. Cellular plasticity throughout metastasis: new insights supplied by intravital microscopy. Cold Spring Harb. Perspect. Med. 10, a037267 (2020).

    Google Scholar 

  • Beerling, E., Oosterom, I., Voest, E., Lolkema, M. & van Rheenen, J. Intravital characterization of tumor cell migration in pancreatic most cancers. IntraVery important 5, e1261773 (2016).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kariya, Y., Oyama, M., Suzuki, T. & Kariya, Y. αvβ3 Integrin induces partial EMT impartial of TGF-β signaling. Commun. Biol. 4, 490 (2021).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mori, S. et al. Enhanced expression of integrin αvβ3 induced by TGF-β is required for the enhancing impact of fibroblast progress issue 1 (FGF1) in TGF-β-induced epithelial-mesenchymal transition (EMT) in mammary epithelial cells. PLoS ONE 10, e0137486 (2015).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Seguin, L. et al. An integrin β3–KRAS–RalB advanced drives tumour stemness and resistance to EGFR inhibition. Nat. Cell Biol. 16, 457–468 (2014).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bellahcène, A., Castronovo, V., Ogbureke, Ok. U., Fisher, L. W. & Fedarko, N. S. Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in most cancers. Nat. Rev. Cancer 8, 212–226 (2008).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Janik, M. E., Lityńska, A. & Vereecken, P. Cell migration—the function of integrin glycosylation. Biochim. Biophys. Acta 1800, 545–555 (2010).

    CAS 
    PubMed 

    Google Scholar 

  • Pocheć, E. et al. Aberrant glycosylation of αvβ3 integrin is related to melanoma development. Anticancer Res. 35, 2093–2103 (2015).

    Google Scholar 

  • Kremser, M. E. et al. Characterisation of α3β1 and αvβ3 integrin N-oligosaccharides in metastatic melanoma WM9 and WM239 cell strains. Biochim. Biophys. Acta 1780, 1421–1431 (2008).

    CAS 
    PubMed 

    Google Scholar 

  • Buescher, J. M. et al. A roadmap for deciphering 13C metabolite labeling patterns from cells. Curr. Opin. Biotechnol. 34, 189–201 (2015).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Elbein, A. D. in Cell Surface and Extracellular Glycoconjugates (eds Roberts, D. D. and Mecham, R. P.) 119–180 (Academic Press, 1993); https://doi.org/10.1016/B978-0-12-589630-6.50009-5

  • Sakai, N., Insolera, R., Sillitoe, R. V., Shi, S.-H. & Kaprielian, Z. Axon sorting inside the spinal twine marginal zone by way of Robo-mediated inhibition of N-cadherin controls spinocerebellar tract formation. J. Neurosci. 32, 15377–15387 (2012).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen, J. Y. et al. A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and most cancers angiogenesis and metastasis pathways. Cancer Res. 71, 473–483 (2011).

    CAS 
    PubMed 

    Google Scholar 

  • Sola-Penna, M., Da Silva, D., Coelho, W. S., Marinho-Carvalho, M. M. & Zancan, P. Regulation of mammalian muscle kind 6-phosphofructo-1-kinase and its implication for the management of the metabolism. IUBMB Life 62, 791–796 (2010).

    CAS 
    PubMed 

    Google Scholar 

  • Rodriguez, A. E. et al. Serine metabolism helps macrophage IL-1β manufacturing. Cell Metab. 29, 1003–1011 (2019).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhao, X., Fu, J., Du, J. & Xu, W. The function of d-3-phosphoglycerate dehydrogenase in most cancers. Int. J. Biol. Sci. 16, 1495–1506 (2020).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ma, C. et al. The different exercise of nuclear PHGDH contributes to tumour progress below nutrient stress. Nat. Metab. 3, 1357–1371 (2021).

    CAS 
    PubMed 

    Google Scholar 

  • Baksh, S. C. et al. Extracellular serine controls epidermal stem cell destiny and tumour initiation. Nat. Cell Biol. 22, 779–790 (2020).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Liu, J. et al. Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead field M1. J. Neurooncol. 111, 245–255 (2013).

    CAS 
    PubMed 

    Google Scholar 

  • Ma, X., Li, B., Liu, J., Fu, Y. & Luo, Y. Phosphoglycerate dehydrogenase promotes pancreatic most cancers improvement by interacting with eIF4A1 and eIF4E. J. Exp. Clin. Cancer Res. 38, 66 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Teoh, S. T., Ogrodzinski, M. P., Ross, C., Hunter, Ok. W. & Lunt, S. Y. Sialic acid metabolism: a key participant in breast most cancers metastasis revealed by metabolomics. Front. Oncol. 8, 174 (2018).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Vandekeere, S. et al. Serine synthesis by way of PHGDH is crucial for heme manufacturing in endothelial cells. Cell Metab. 28, 573–587 (2018).

    CAS 
    PubMed 

    Google Scholar 

  • Kim, D., Langmead, B. & Salzberg, S. L. HISAT: a quick spliced aligner with low reminiscence necessities. Nat. Methods 12, 357–360 (2015).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wright, G. W. & Simon, R. M. A random variance mannequin for detection of differential gene expression in small microarray experiments. Bioinformatics 19, 2448––2455 (2003).

    PubMed 

    Google Scholar 

  • Paulo, J. A. & Gygi, S. P. Nicotine-induced protein expression profiling reveals mutually altered proteins throughout 4 human cell strains. Proteomics 17, 1600319 (2017).

    Google Scholar 

  • Bassez, A. et al. A single-cell map of intratumoral modifications throughout anti-PD1 remedy of sufferers with breast most cancers. Nat. Med. 27, 820–832 (2021).

    CAS 
    PubMed 

    Google Scholar 

  • Zhang, X. et al. A renewable tissue useful resource of phenotypically secure, biologically and ethnically various, patient-derived human breast most cancers xenograft fashions. Cancer Res. 73, 4885 (2013).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lv, X. et al. Orthotopic transplantation of breast tumors as preclinical fashions for breast most cancers. J. Vis. Exp. 159, e61173 (2020).

  • Quintana, E. et al. Human melanoma metastasis in NSG mice correlates with scientific final result in sufferers. Sci. Transl. Med. 4, 159ra149 (2012).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Bankhead, P. et al. QuPath: open supply software program for digital pathology picture evaluation. Sci. Rep. 7, 16878 (2017).

    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Berg, S. et al. ilastik: interactive machine studying for (bio)picture evaluation. Nat. Methods 16, 1226–1232 (2019).

    CAS 
    PubMed 

    Google Scholar 

  • Carpenter, A. E. et al. CellProfiler: picture evaluation software program for figuring out and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Zanotelli, V. R. T. & Bodenmiller, B. ImcSegmentationPipeline: a pixelclassification primarily based multiplexed picture segmentation pipeline. Zenodo https://doi.org/10.5281/zenodo.3841961 (2020).

  • Schindelin, J. et al. Fiji: an open-source platform for biological-image evaluation. Nat. Methods 9, 676–682 (2012).

    CAS 
    PubMed 

    Google Scholar 

  • Rueden, C. T. et al. ImageJ2: ImageJ for the subsequent technology of scientific picture information. BMC Bioinform. 18, 529 (2017).

    Google Scholar 

  • van Gorsel, M., Elia, I. & Fendt, S.-M. 13C tracer evaluation and metabolomics in 3D cultured most cancers cells. Methods Mol. Biol. 1862, 53–66 (2019).

    PubMed 

    Google Scholar 

  • Young, J. D., Walther, J. L., Antoniewicz, M. R., Yoo, H. & Stephanopoulos, G. An elementary metabolite unit (EMU) primarily based methodology of isotopically nonstationary flux evaluation. Biotechnol. Bioeng. 99, 686–699 (2008).

    CAS 
    PubMed 

    Google Scholar 

  • Fernandez, C. A., Des Rosiers, C., Previs, S. F., David, F. & Brunengraber, H. Correction of 13C mass isotopomer distributions for pure secure isotope abundance. J. Mass Spectrom. 31, 255–262 (1996).

    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Next Post
    Eliminate role of middlemen in agriculture sector, says PM

    Eliminate role of middlemen in agriculture sector, says PM

    Leave a Reply Cancel reply

    Your email address will not be published. Required fields are marked *

    Categories

    • Agriculture
    • Animals
    • Business
    • Economy
    • Education
    • Entertainment
    • Life Style
    • Nature
    • Sports
    • Travel
    • World

    Recommend

    Fight slavery's 'racist legacy' through education: Guterres – UN News

    Fight slavery's 'racist legacy' through education: Guterres – UN News

    March 25, 2023
    Farm to table: Foust students learn about agriculture, healthy eating – messenger-inquirer

    Farm to table: Foust students learn about agriculture, healthy eating – messenger-inquirer

    March 25, 2023
    it's almost time to get wild about nature – YourSun.com

    it's almost time to get wild about nature – YourSun.com

    March 25, 2023
    Wheeling Solicitor Delivers More Bite to City's Canine Codes – Wheeling Intelligencer

    Wheeling Solicitor Delivers More Bite to City's Canine Codes – Wheeling Intelligencer

    March 25, 2023
    The government had announced a $10 billion package to incentivise

    The government had announced a $10 billion package to incentivise

    March 25, 2023
    Effingham Unit #40 Board of Education to Meet Monday – Samantha Laturno

    Effingham Unit #40 Board of Education to Meet Monday – Samantha Laturno

    March 25, 2023

    Archives

    • March 2023
    • February 2023
    • January 2023
    • December 2022
    • November 2022
    • October 2022
    • September 2022
    • August 2022
    • July 2022
    • June 2022
    • May 2022
    • April 2022
    • March 2022
    • February 2022
    • January 2022
    • December 2021
    • November 2021
    • October 2021
    • September 2021
    • August 2021

    Meta

    • Register
    • Log in
    • Entries feed
    • Comments feed
    • WordPress.org

    Categories

    • Agriculture
    • Animals
    • Business
    • Economy
    • Education
    • Entertainment
    • Life Style
    • Nature
    • Sports
    • Travel
    • World
    • About
    • About us
    • Agriculture
    • Community
    • Contact US
    • Contact us
    • Home
    • Home 2
    • Home 3
    • Home 4
    • Home 5
    • Nature
    • Privacy policy
    • Privacy Policy
    • Sample Page
    • Terms and conditions

    © GreenHeartSoup - All Rights Are Reserved

    No Result
    View All Result
    • Home
    • World
    • Business
    • Sports
    • Agriculture
    • Nature
    • Animals
    • Economy
    • Education
    • Entertainment
    • Life Style
    • Travel

    © GreenHeartSoup - All Rights Are Reserved

    Welcome Back!

    Login to your account below

    Forgotten Password? Sign Up

    Create New Account!

    Fill the forms below to register

    All fields are required. Log In

    Retrieve your password

    Please enter your username or email address to reset your password.

    Log In
    We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may visit "Cookie Settings" to provide a controlled consent.
    Cookie SettingsAccept All
    Manage consent

    Privacy Overview

    This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
    Necessary
    Always Enabled
    Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
    CookieDurationDescription
    cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
    cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
    cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
    cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
    cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
    viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
    Functional
    Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
    Performance
    Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
    Analytics
    Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
    Advertisement
    Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
    Others
    Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
    SAVE & ACCEPT